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EXPERIMENT INFORMATION

Study of Muscarinic and GABA (Benzodiazepine) Receptors in the Sensory-Motor Cortex, Hippocampus, and Spinal Cord (COS 1887-9)
Principal Investigator
Research Area:
Neurophysiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

In this experiment, frontal lobe samples from brains of space-flown rats were processed for the study of muscarinic (cholinergic) and GABA (benzodiazepine) receptors, and for immunocytochemical localization of the neurotransmitter gamma-aminobutyric acid (GABA) and glial fibrillary acidic protein (GFAP). The aim was to explore the feasibility of investigating neurotransmitters and their receptors in space flight experiments.


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Publications
Daunton, N.G. et al.: Study of Muscarinic and GABA (Benzodiazepine) Receptors in the Sensory-Motor Cortex, Hippocampus, and Spinal Cord. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 365-370.

Keywords
GABA
Receptors, GABA
Glial fibrillary acidic protein (GFAP)
Frontal lobe
Receptors, muscarinic

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Content, Gamma-aminobutyric acid, in cerebral cortex, rat, Immunocytochemistry, microscopy
Content, Glial fibrillary acidic protein (GFAP), in cerebral cortex, rat, Immunocytochemistry, microscopy
Content, Neurotransmitter (GABA), in forebrain, rat, Immunocytochemistry, microscopy
Count, Cholinergic receptors, cerebral cortex, brain, rat, Radiography binding
Count, Gamma-aminobutyric acid (GABA) receptors, cerebral cortex, brain, rat, Radiography binding
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1887-14
Protocol / Approach
Hardware Items