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Association Between Age and PSA Values in LSAH Participants (LSAHNEWSV5_2)
Research Area:
Clinical medicine
Species Studied
Scientific Name: Homo sapiens Species: Human

Male participants in the LSAH have been offered prostate-specific antigen (PSA) screening since 1993. The results of these tests are used, on an individual basis, to assess the need for more extensive screening for prostate cancer. The LSAH now has enough group data to provide population information about the normal ranges of the test values and the variation in values associated with age.

The normal range of values is generally considered to be 0 to 4 ng/mL (nanograms per milliliter of serum), with higher values prompting further investigation and testing. However, questions have been raised about the upper level of this standard because a significant number of older men in the general population, whose values exceed the range, may have received more extensive testing than necessary.

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National Aeronautics and Space Administration. Association between age and PSA values. In: Longitudinal Study of Astronaut Health Newsletter. Fall 1996;5(2):1-4.

Oesterling JE, et al. Free, complexed and total serum prostate specific antigen: the establishment of appropriate reference ranges for their concentrations and ratios. Journal of Urology. 154(3):1090-5, 1995.[]

Prostate-specific antigen

Prostate specific antigen (PSA)

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
LSAH 01/01/1989 05/31/2010 21 years

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Jessica Keune
Institutional Support
National Aeronautics and Space Administration (NASA)