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EXPERIMENT INFORMATION

The Effect of Cosmos 1887 Flight on Spermatogonial Population and Testosterone Level in Rat Testes (COS 1887-19)
Principal Investigator
Research Area:
Developmental biology
Endocrinology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Immobilization, applied for a short or long period, is considered a form of physiological stress. Most reports indicate that stress decreases testosterone levels, but does not cause any morphological changes in the seminiferous tubules. On the other hand, irradiation, depending on the dosage, can result in the depletion of all spermatogonial cells except a few stem cells, while testosterone levels do not seem to be affected either in serum or intratesticular tissue. This experiment was to further understand space flight effects on the testes.


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Publications
Philpott, D.E. et al.: The Effect of Cosmos 1887 Flight on Spermatogonial Population and Testosterone Level in Rat Testes. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 345-358.

Sapp, W. et al.: Preliminary Report of a Comparative Study of Seminiferous Tubular Epithelium from Rats Flown on Cosmos 1887 and SL-3. Proc. Elec. Soc. Am., vol. 46, 1988, p. 276.

Keywords
Testosterone
Immobilization
Testis
Spermatogonia

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Cell function: Leydig cell
Cell ultrastructure: Leydig cell
Count, Sertoli cells, testes, rat, Histochemistry, microscopy
Count, Spermatids, testes, rat, Histochemistry, microscopy
Damage, Developmental abnormalities, rat, Microscopy
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1887-19
Protocol / Approach
Hardware Items