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EXPERIMENT INFORMATION

Effect of Spaceflight on Levels and Function of Immune Cells (COS 1887-16)
Principal Investigator
Research Area:
Immunology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

The purpose of this experiment was to begin a systematic attempt to define the range of immunological parameters affected by space flight. Two different areas were chosen for study. First, the effect of space flight on the ability of cells to respond to an external immunological stimulus was determined. Second, the effects of space flight on the expression of cell surface markers of spleen and bone marrow cells was examined. These markers represent various immunologically important cell populations; an alteration in the percentage of cells expressing the markers could result in an alteration of the immunological function.


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Publications
Konstantinova, I.V. et al.: Results of Immunological Experiments Aboard the Cosmos Biosatellites and Problems in Space Immunology. Physiologist, supl., vol. 35, no. 1, 1992, pp. S220-S221.

Mandel, A.D. et al.: Effect of Spaceflight on Levels and Function of Immune Cells. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 471-480.

Sonnenfeld G, Mandel AD, Konstantinova IV, Berry WD, Taylor GR, Lesnyak AT, Fuchs BB, Rakhmilevich AL: Effects of Spaceflight on Immune Responses: Bone Marrow Cell Responses to Colony Stimulating Factor and Leukocyte Subsets. Physiologist, supl., vol. 35, no. 1, 1992, pp. S222-S223.

Sonnenfeld G, Mandel AD, Konstantinova IV, Taylor GR, Berry WD, Wellhausen SR, Lesnyak AT, Fuchs BB: Effect of Spaceflight on Levels and Activity of Immune Cells. Aviation, Space, and Environmental Medicine, vol. 61, 1990, pp. 648-653.

Keywords
Antigen-antibody reactions
Bone marrow
Bone marrow cells
Immunity
Lymphocytes
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Count, Leukocytes, white cells, spleen, rat, Clinical laboratory
Count, Lymphocytes, large, white cells, bone marrow, rat, Clinical laboratory
Count, Lymphocytes, small, white cells, bone marrow, rat, Clinical laboratory
Count, Myeloid cells, immature, bone marrow, rat, Clinical laboratory
Count, Myeloid cells, mature, bone marrow, rat, Clinical laboratory
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1887-2
Protocol / Approach
Hardware Items