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EXPERIMENT INFORMATION

Bed Rest and Immunity (BEDREST0037)
Principal Investigator
Research Area:
Immunology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
Exposure of humans to space flight conditions results in immune responses. The contribution of these changes in the immune system to alterations in resistance to infection and tumors remains to be fully established. The head down tilt bed rest model has been established as valid for studying the effects of space flight conditions on functional dynamic immune responses such as cytokine production. The proposed study is designed to determine the effects of bed rest on immune responses of subjects. The overall hypothesis to be tested is: maintenance of subjects in the head down tilt bed rest model will result in suppression of functional immune responses and enhance susceptibility to infection. The specific aims of the proposed study are: to determine the effects of maintenance of subjects in the head down tilt bed rest model on functional immune responses, and resistance to infection. The effects of bed rest on immune function and control of viral infections will be correlated to space flight.


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Publications
Shearer, W.T., Ochs, H.D., Lee, B.N., Cohen, E.N., Reuben, J.M., Cheng, I., Thompson, B., Butel, J.S., Blancher, A., Abbal, M., Aviles, H., Sonnenfeld, G. Immune responses in adult female volunteers during bed-rest model of space flight: antibodies and cytokines. J. Allergy Clin. Immunol. 123, 900-905, 2009.[pubmed.gov]

Sonnenfeld G, Avilesa H, Butel JS, Shearer WT, Nieself D, Pandyaf U, Allen C, Ochsg HD, Blancher A, Abbal M. Bed Rest and Immunity. Acta Astronautica Volume 60, Issues 4-7, February-April 2007, Pages 234-236.

Keywords
Herpesvirus 3, human/physiology
Immunity, cellular
Leukocytes
T-Lymphocytes, helper-inducer
Virus
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Anti interleukin 10
Herpes virus
Interleukin 12
Interleukin 1RA
Leukocyte proliferation
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Campaign 1 08/29/2004 11/21/2004 84 days

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

The Human Research Roadmap is located at: https://humanresearchroadmap.nasa.gov/

+ Click here for information of how this experiment is contributing to the HRP's path for risk reduction.

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Pamela A. Bieri
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Source
BEDREST2003-0002-0037