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EXPERIMENT INFORMATION

The Effect of Spaceflight on Pituitary Oxytocin and Vasopressin Content of Rats (COS 1887-36)
Principal Investigator
Research Area:
Endocrinology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Disturbances in fluid and electrolyte balance have been noted in humans exposed to space flight. Similar postflight fluid-electrolyte and hormone responses have been observed in rats that were exposed to microgravity. Microscopic examination of the hypothalamus and posterior pituitary gland of flight rats exposed to space flight shows changes indicative of increased activity (e.g. increased hormone synthesis and secretion). The purpose of this investigation was to measure levels of pituitary oxytocin (OT) and vasopressin (AVP) as possible indicators of changes in fluid-electrolyte balance during space flight.


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Publications
Keil, L.C. et al.: The Effect of Spaceflight on Pituitary Oxytocin and Vasopressin Content of Rats. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 387-392.

Keywords
Fluid shifts
Hypothalamus
Motion sickness
Oxytocin
Pituitary gland
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Content, Oxytocin, pituitary, rat, Radioimmunoassay
Content, Pituitary hormone per mg protein, rat, Calculation
Content, Protein, pituitary, rat, Assay versus BSA
Content, Vasopressin, pituitary, rat, Radioimmunoassay

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1887-22
Protocol / Approach
Hardware Items