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EXPERIMENT INFORMATION

Bed Rest Standard Measures: Hepatic and Renal Function (BRSMRF)
Principal Investigator
Research Area:
Pharmacology
Renal, fluid and electrolyte physiology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
Gastrointestinal (GI) function plays a critical role in the absorption and bioavailability of orally administered drugs. Further, the GI tract plays a pivotal role in the bioavailability of nutrients. The availability of energy depends on intake, absorption, storage, and utilization. The absorption and bioavailability of ingested compounds depend on physiological factors such as GI motility, splanchnic blood flow, and pH of gastric secretions.

Changes in albumin and creatinine are established indices for hepatic and renal function. Previous studies looking at albumin creatinine ratios found a 10 percent change depending on the length of bed rest. The normal ratio is .8-.13 mg/dl creatinine and 3.7-5.2g/dl albumin. Individual values are usually consistent under controlled conditions.


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Keywords
Albumins
Creatine
Pharmacokinetics
Liver

Data Information
Data Availability
Archive is complete. Data sets are not publicly available but can be requested.
Data Sets+ Request data

Parameters
Creatinine clearance
Serum albumin

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Campaign 1 08/29/2004 11/21/2004 84 days
Campaign 3 02/20/2005 04/14/2010 5 years, 1 month, 25 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Pamela A. Bieri
Institutional Support
National Aeronautics and Space Administration (NASA)