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EXPERIMENT INFORMATION

Effect of Microgravity on: I. Metabolic Enzymes of Individual Muscle Fibers (COS 1887-34)
Research Area:
Metabolism and nutrition
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

The individual fibers of any muscle vary greatly in enzyme composition, a fact which is obscured when enzyme levels of a whole muscle are measured. The purpose of this study was, therefore, to assess the changes due to weightlessness on the enzyme patterns composed by the individual fibers within the muscles of rats subjected to space flight.


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Publications
Lowry, O. et al.: Effect of Microgravity On: I. Metabolic Enzymes of Individual Muscle Fibers. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 393-411.

Manchester, J.K. et al.: Effect of Microgravity on Metabolic Enzymes on Individual Muscle Fibers. FASEB Journal, vol. 4, no. 1, 1990, pp. 55-63.

Keywords
Muscle fibers, fast-twitch
Muscle fibers, slow-twitch
Enzymes
Citrate (si)-synthase
Lactate dehydrogenase (LDH)

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Glycolytic, glycogenic, oxidative enzymes, soleus, muscle, rat, Assay
Activity, enzymic, Glycolytic, glycogenic, oxidative enzymes, tibialis anterior, muscle, rat, Assay
Activity, enzymic, Malate dehydrogenase (MDH), soleus, muscle, rat, Assay
Activity, enzymic, Malate dehydrogenase (MDH), tibialis anterior, muscle, rat, Assay
Properties, type, Fiber, muscle, rat, Hexokinase, enzymic
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1887-23.1
Protocol / Approach
Hardware Items