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EXPERIMENT INFORMATION

Effect of Microgravity on: II. Metabolic Enzymes of Hippocampus and Spinal Cord (COS 1887-35)
Research Area:
Neurophysiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

The question of possible enzyme changes due to exposure to microgravity is much more complicated in the case of the central nervous system than it is for skeletal muscle. The brain is enormously complex. Valid comparisons must be made between exactly the same regions of control and flight brains, otherwise natural differences will confuse the issue. This study compares flight and synchronous enzymes from the hippocampus and spinal cord with regards to specific regions.


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Publications
Lowry, O. et al.: Effect of Microgravity On: II. Metabolic Enzymes of Hippocampus and Spinal Cord. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 413-418.

Keywords
Citrate (si)-synthase
Enzymes
Glutaminase
Hexokinase
Hippocampus
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Citrate synthase (CS), hippocampus, brain, rat, Assays (enzyme units)
Activity, enzymic, Gamma-aminobutyric acid (GABA), hippocampus, brain, rat, Assays (enzyme units)
Activity, enzymic, Glutamate decarboxylase (GAD), hippocampus, brain, rat, Assays (enzyme units)
Activity, enzymic, Glutaminase, hippocampus, brain, rat, Assays (enzyme units)
Activity, enzymic, Hexokinase, hippocampus, brain, rat, Assays (enzyme units)
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1887-23.2
Protocol / Approach
Hardware Items