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Strain-gauge Plethysmographic Analysis of the CErebral DRainage Experimented and Assessed in the Micro-gravitational Setting (Drain_Brain)
Principal Investigator
Research Area:
Cardiovascular physiology
Species Studied
Scientific Name: Homo sapiens Species: Human

A strain-gauge plethysmography system will be developed and used to investigate cerebral venous return in microgravity conditions and to understand the phenomena of physiological adaptation.

Strain-gauge plethysmography is a non-invasive technique that measures variations in electrical resistance associated with changes in blood volume, recorded through a sensor encircling any cylindrical segment of the body, including the neck. The required hardware is easily transported, is not operator-dependent, and is non-invasive making it ideal to study the modality of brain venous drainage in microgravity.

The aim of the experiments to be carried out on board the ISS is threefold:
1. Study of the cerebral venous return (CVR) in a microgravity environment by measuring changes in neck volume as a function of the postural conditions.
2. Study of the circadian rhythm (CVR chronobiology) by means of the analysis of on-board CVR.
3. Assessment of the processes of physiological adaptation by means of basal spirometry and echo color Doppler sonography.

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Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

Basal spirometry
Blood pressure
Heart rate
Jugular vein, cross section area
Neck volume

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Expedition 42 11/10/2014 03/11/2015 121 days
Expedition 43 03/11/2015 06/10/2015 91 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Jessica Keune
Institutional Support
Italian Space Agency (ASI)
Alternate Experiment Name
Hardware Items