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EXPERIMENT INFORMATION

Distribution and Biochemistry of Mineral and Matrix in the Femurs of Rats (COS 1887-8)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Previous analyses of the composition of mineral and matrix in the bone of young rats following space flight has revealed deficits in calcium, phosphorus, and osteocalcin, a noncollagenous protein, without an associated decrease in collagen. To characterize the location and nature of this mineralization defect in a weight bearing long bone, the femur, this study attempted to relate the spatial distribution of mineral in situ in the proximal, central, and distal thirds of the femoral diaphysis to the biochemical composition of the bone from the same areas.


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Publications
Arnaud, S.B. et al.: Distribution and Biochemistry of Mineral and Matrix in the Femurs of Rats. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 63-84.

Mechanic, G.L. et al.: Regional Distribution of Mineral and Matrix in the Femurs of Rats Flown on Cosmos 1887 Biosatellite. FASEB Journal, vol. 4, no. 1, 1990, pp. 34-40.

Keywords
Alkaline phosphatase (AP)
Bone density
Calcification, physiologic
Calcium
Collagen
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Alkaline phosphatase (AP), serum, rat, Analyzer
Bone mineralization: femur
Calcium, total: serum
Content, Calcium, femur, bone, rat, Automated analyzer
Content, Calcium, femur, bone, rat, X-ray microtomography
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1887-3
Protocol / Approach
Hardware Items