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EXPERIMENT INFORMATION

Gravity and Skeletal Growth: III. Nuclear Volume Analysis of Osteoblast Histogenesis in Periodontal Ligament Cells of Cosmos 1887 Rats (COS 1887-5)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Bone is a mechanically sensitive tissue that is particularly responsive to gravitational forces. An understanding of changes in bone mass is important since it functions not only as structural support, but also as a metabolic source of calcium. The periodontal ligament (PDL), a well defined cell kinetic model for assessing the proliferation and differentiation of the cells associated with osteoblast histogenesis, was used to study the effect on osteoblast production.


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Publications
Fielder, P.J. et al.: Osteoblast Histogenesis in Periodontal Ligament and Tibial Metaphysis During Simulated Weightlessness. Aviation, Space, and Environmental Medicine, vol. 57, 1986, pp. 1125-1130.

Garetto, L.P. et al.: Gravity and Skeletal Growth: III. Nuclear Volume Analysis of Osteoblast Histogenesis in Periodontal Ligament Cells of Cosmos 1887 Rats. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990,
pp. 139-146.

Garetto, L.P. et al.: Preosteoblast Production 55 Hours after a 12.5 Day Spaceflight on Cosmos 1887. FASEB Journal, vol. 4, no. 1, 1990, pp. 24-28.

Keywords
Bone development
Osteoblasts
Periodontal ligament (PDL)
Osteogenesis

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Count, Osteoblast, periodontal ligament (PDL), rat, Histology, microscopy
Count, Osteoprogenitors, periodontal ligament (PDL), rat, Histology, microscopy
Count, Precursor cells, periodontal ligament (PDL), rat, Histology, microscopy
Count, Preosteoblasts, periodontal ligament (PDL), rat, Histology, microscopy
Formation, Bone, maxillea, rat, Morphometry
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1887-5.3
Protocol / Approach
Hardware Items