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Morphometric and EM Analysis of Tibial Epiphyseal Plates From Cosmos 1887 Rats (COS 1887-32)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar


Studies have shown that bone formation ceases during space flight, that the matrix formed during flight does not mature normally, and consequently cannot mineralize normally. The cartilaginous epiphyses of the long bones of space rats have received less attention, even though some of the changes that are seen in bone (e.g. decreased length and decreased trabecular mass) must originate in the epiphyseal region. The objectives of the present study were to look for differences in plate parameters and cell and matrix ultrastructure, in proximal tibial epiphyseal plates of space-flown rats.

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Duke, P.J. et al.: Altered Cartilage Differentiation in Tibial Epiphyseal Plates of Cosmos Rats. Proceedings of the 4th European Symposium on Life Sciences Research in Space, V. David, ed., Trieste, Italy, May 28-June 1, 1990, pp. 269-273.

Duke, P.J. et al.: Histomorphometric and Electron Microscopic Analyses of Tibial Epiphyseal Plates from Cosmos 1887 Rats. FASEB Journal, vol. 4 no. 1, 1990, pp. 41-46.

Duke, P.J. et al.: Morphometric and EM Analysis of Tibial Epiphyseal Plates From Cosmos 1887 Rats. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 169-182.

Montufar-Solis, D. and P.J. Duke: Changes in the Rat Growth Plates Due to Strain, Diet and Housing. American Society for Gravitational and Space Biology Bulletin, vol. 3, no. 1, 1989, p. 114.

Montufar-Solis, D. and P.J. Duke: Effects of Strain, Diet and Housing on Rat Growth Plates: a Cosmos '87 - Spacelab-3 Comparison. Physiologist, supl., vol. 34, no. 1, 1991, pp. S183-S184.

Bone matrix
Bone mineralization
Bone development
Growth plate

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Formation, Bone, in tibia, rat, Microscopy
Formation, Bone, in tibia, rat, Optical diffraction,
Morphology, Growth plate, tibia, bone, rat: Microscopy
Morphology, Matrix, tibia, bone, rat: Microscopy
Morphometry, Calcification, cartilage, tibia, bone, rat, Microscopy, digitizing tablet
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Protocol / Approach
Hardware Items