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EXPERIMENT INFORMATION

Metabolic and Morphologic Properties of Muscle Fibers After Spaceflight (COS 1887-26)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

It is apparent that a variety of biochemical and physiological properties of the rat skeleton are altered following 5-22 days of exposure to microgravity. Since these studies have been based primarily on the analysis of whole muscle properties and given the potential difference in the response of muscle fibers differing in alkaline adenosine triphosphatase (ATPase) type and size, the purposes of this study were: 1) to define the size and metabolic responses of single fibers to space flight and 2) to determine the specificity of these responses to the muscle and the myosin type and size of its fibers.


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Publications
Alford, E.K. et al.: Electromyography of Rat Soleus, Medial, Gastrocnemius and Tibialis Anterior During Hind Limb Suspension. Experimental Neurology, vol. 96, 1987, pp. 635-649.

Edgerton, V.R. et al.: Metabolic and Morphologic Properties of Muscle Fibers After Spaceflight. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 183-205.

Graham, S.C. et al.: Effects of Periodic Weight Support on Medial Gastrocnemius Fibers of Suspended Rats. Journal of Applied Physiology, vol. 67, no. 3, 1989, pp. 945-953.

Hauschka, E.O. et al.: Size and Metabolic Properties of Single Muscle Fibers in Rat Soleus After Hindlimb Suspension. Journal of Applied Physiology, vol. 62, no. 6, 1987, pp. 2338-2347.

Miu, B. et al.: Metabolic and Morphologic Properties of Single Muscle Fibers in the Rat after Spaceflight. FASEB Journal, vol. 4, no. 1, 1990, pp. 64-72.

Roy, R. et al.: Size and Metabolic Properties of Fibers in Rat Fast Twitch Muscles after Hindlimb Suspension. Journal of Applied Physiology, vol. 62, 1987, pp. 2348-2357.

Roy RR, Hutchison DL, Hodgson JA, and Edgerton VR., EMG amplitude pattern in rat soleus and medial gastrocnemius following seven days of hindlimb suspension. Engineering in Medicine and Biology Society, 1988. doi: 10.1109/IEMBS.1988.94934. [DOI]

Hauschka EO, Roy RR, Edgerton VR., Periodic weight support effects on rat soleus fibers after hindlimb suspension., J Appl Physiol. 1988 Sep;65(3):1231-7. pubmed.gov

Winiarski AM, Roy RR, Alford EK, Chiang PC, Edgerton VR., Mechanical properties of rat skeletal muscle after hind limb suspension., Exp Neurol. 1987 Jun;96(3):650-60. pubmed.gov

Herbert ME, Roy RR, Edgerton VR., Influence of one-week hindlimb suspension and intermittent high load exercise on rat muscles., Exp Neurol. 1988 Nov;102(2):190-8. pubmed.gov

Keywords
Muscle fibers
Adenosinetriphosphatase (ATPase)
Succinate dehydrogenase (SDH)
Glycerolphosphate dehydrogenase
Myosin

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Adenosine triphosphatase (ATPase), soleus, muscle, rat, Assay
Activity, enzymic, Glycerophosphate dehydrogenase, gastrocnemius, muscle, rat, Assay
Activity, enzymic, Glycerophosphate dehydrogenase, soleus, muscle, rat, Assay
Activity, enzymic, Glycolytic, glycogenic, oxidative enzymes, soleus, muscle, rat, Assay
Activity, enzymic, Reaction product, chemical, rat, Microscopy, optical density, activity (OD per minute)
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1887-8
Protocol / Approach
Hardware Items