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Biochemical and Histochemical Observations of Vastus Medialis (COS 1887-29)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar


The principal objectives of this study were to ascertain if the vastus medialis (VM) responded to microgravity exposure. Three approaches were used: 1) a histochemical evaluation of cellular morphology (fibers and capillaries); 2) an assessment of biochemical composition (protein, RNA and DNA concentrations) and 3) an estimation of metabolic activities and capacities (oxidative and glycolytic metabolism).

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Musacchia, X.J. et al.: Biochemical and Histochemical Observations of Vastus Medialis from Rats Flown in Cosmos 1887. Physiologist, supl., vol. 32, no. 1, 1989, pp. S21-S22.

Musacchia, X.J. et al.: Biochemical and Histochemical Observations of Vastus Medialis. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 207-214.

Steffen, J.M. and X.J. Musacchia: Effect of Hypokinesia and Hypodynamia on Protein, RNA and DNA in Rat Hindlimb Muscles. American Journal of Physiology, vol. 247, 1984, pp. R728-R732.

Muscular atrophy
Citrate (si)-synthase
Lactate dehydrogenase (LDH)
Muscle fibers

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Activity, enzymic, Citrate synthase (CS),vastus medialis, muscle, rat, Assay
Activity, enzymic, Lactate dehydrogenase (LDH), vastus medialis, muscle, rat, Assay
Area, cross section, Capillaries, vastus medialis, muscle, rat, Histology, microscopy
Content, DNA, vastus medialis, muscle, rat, Biochemical
Content, Lipids, in vastus medialis, muscle, rat
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Protocol / Approach
Hardware Items