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Morphometric and EM Analyses of Tibial Epiphyseal Plates from Cosmos 2044 Rats (COS 2044-45)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar


Previous studies have shown that space flight has significant effects on cartilage differentiation within the growth plate, changes which could lead to the observed decreases in linear bone growth and trabecular bone mass. In this study, growth plates of rats flown aboard Cosmos 2044 were analyzed by the same histomorphometric and electron microscopic methods used for other flights and compared to appropriate controls.

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Duke, P.J. and D. Montufar-Solis: A Preliminary Report on Histomorphometry of Tibial Epiphyseal Plates from Cosmos 2044 Rats. American Society for Gravitational and Space Biology Bulletin, vol. 4, no. 1, 1990, p. 35.

Duke, P.J. et al.: Altered Cartilage Differentiation in Tibial Epiphyseal Plates of Cosmos Rats. Proceedings of the 4th European Symposium on Life Sciences Research in Space, V. David, ed., Trieste, Italy, May 28-June 1, 1990, pp. 269-273.

Duke, P.J. et al.: Morphometric and EM Analyses of Tibial Epiphyseal Plates from Cosmos 2044 Rats. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 1. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 235-251.

Montufar-Solis, D. et al.: Spaceflight and Age Affect Tibial Epiphyseal Growth Plate Histomorphometry. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. S19-S25.

Vergara, J. et al.: Space Flight Effects Metaphyseal Vascularization of Rat Tibias. American Society for Gravitational and Space Biology Bulletin, vol. 6, no. 1, 1992, p. 50.

Growth plate
Cell differentiation

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Formation, Bone, in tibia, rat, Microscopy
Formation, Bone, in tibia, rat, Optical diffraction,
Morphology, Growth plate, tibia, bone, rat: Microscopy
Morphology, Matrix, tibia, bone, rat: Microscopy
Morphometry, Calcification, cartilage, tibia, bone, rat, Microscopy, digitizing tablet
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Protocol / Approach
Proposal Date
Proposal Source
Hardware Items