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Bed Rest Standard Measures: General Immunity (BRSMImmune)
Principal Investigator
Research Area:
Species Studied
Scientific Name: Homo sapiens Species: Human

Prolonged exposure to reduced gravity, physiological stress or other factors associated with space flight may result in immune system dysregulation. Latent herpesvirus reactivation, a measurable result of dysregulated immunity, has been detected in crewmembers during and immediately following space missions.

A panel of assays was designed to monitor immune system dysregulation, viral reactivation, and physiological stress. These assays will be applied to a future ISS/Shuttle Supplemental Medical Objective (SMO). This assay panel is also appropriate to monitor the status and function of the immune system, viral reactivation, and physiological stress during ground-based analog studies. These assays will be included on all future bed rest campaigns for the purpose of monitoring the immune status of the participants. While bed rest is not the most appropriate model for space flight-associated immune dysregulation, it is possible that the various countermeasures proposed for evaluation during bed rest may affect immune function. For this reason, the immune function of the participants will be monitored.

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Crucian BE, Stowe RP, Mehta SK, Yetman DL, Leal MJ, Quiriarte HD, Pierson DL, Sams CF. Immune status, latent viral reactivation, and stress during long-duration head-down bed rest. Aviation, Space, and Environmental Medicine. 2009. May; 80(5 Suppl):A37-44.[]

Metcha SK, Crucian B, Pierson DL, Sams C, Stowe RP. Monitoring immune system function and reactivation of latent viruses in the Artificial Gravity Pilot study. Journal of Gravitational Physiology. 2007. July; 14(1):P21-5. []

Bed rest
Immune system
Stress, psychological/immunology
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Data Information
Data Availability
Archive is complete. Data sets are not publicly available but can be requested.
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B cells
CD4+ 3/28
CD4+ T cells
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Campaign 11 05/11/2011 12/15/2014 3 years, 7 months, 4 days
Campaign 3 02/20/2005 04/14/2010 5 years, 1 month, 25 days
Campaign 5 04/30/2006 12/23/2007 1 year, 7 months
DBLS 05/03/2010 05/23/2010 Discontinued
Pilot 02/05/2006 12/22/2006 320 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Jessica Keune
Institutional Support
National Aeronautics and Space Administration (NASA)