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Human Cerebral Cortex Plasticity in Response to Long-term Bedrest as an Analog to Microgravity (NSBRI20010036)
Principal Investigator
Research Area:
Species Studied
Scientific Name: Homo sapiens Species: Human

This investigation assesses the effects of weightlessness on the central nervous system and specifically the sensorimotor system by inducing cortical reorganization through altered cortical excitability. The measures of cortical excitability will be evaluated for correlation with measures of lower limb functional recovery.

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Roberts DR, Ramsey D, Johnson K, Kola J, Ricci R, Hicks C, Borckardt JJ, Bloomberg JJ, Epstein C, and George MS. Cerebral cortex plasticity after 90 days of bed rest: data from TMS and fMRI. Aviation, Space, and Environmental Medicine. 2010. January; 81(1):30-40.[]

Roberts DR, Zhu X, Tabesh A, Duffy EW, Ramsey DA, and Brown TR. Structural brain changes following long-term 6º head-down tilt bed rest as an analog for spaceflight. AJNR American Journal of Neuroradiology. July 16, 2015. []

Adaptation, physiological
Bed rest
Cerebral cortex
Magnetic resonance imaging (MRI)
Neuronal plasticity
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Data Information
Data Availability
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Corticospinal plasticity
Motor cortex excitability
Motor evoked potentials

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Campaign 3 02/20/2005 04/14/2010 5 years, 1 month, 25 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Jessica Keune
Institutional Support
National Space Biomedical Research Institute (NSBRI)
Alternate Experiment Name
Proposal Date
Proposal Source