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Skeletal Muscle Atrophy in Response to 14 Days of Weightlessness (COS 2044-34)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar


Muscles of the rat hind limb have been used to demonstrate the effects of unloading in weightlessness and in models developed to mimic the response seen during exposure to microgravity. The principal objectives of this study were to ascertain how the vastus medialis (VM) responded to fourteen days of microgravity and if hind limb unloading (tail-suspension) was comparable to microgravity.

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Musacchia, X.J. et al.: Skeletal Muscle Atrophy in Response to 14 Days of Weightlessness - Vestus Medialis. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. S44-S50.

Musacchia, X.J. et al.: Skeletal Muscle Atrophy in Response to 14 Days of Weightlessness. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 1. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 271-288.

Musacchia, X.J.: An Assessment of Suspension Systems: Models That Reproduce Responses to Weightlessness. Physiologist, supl., vol. 35, no. 1, 1992, pp. S92-S95.

Citrate (si)-synthase
Lactate dehydrogenase (LDH)
Muscle fibers, fast-twitch
Muscle fibers, slow-twitch
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Activity, enzymic, Citrate synthase (CS),vastus medialis, muscle, rat, Assay
Activity, enzymic, Lactate dehydrogenase (LDH), vastus medialis, muscle, rat, Assay
Area, cross section, Capillaries, vastus medialis, muscle, rat, Histology, microscopy
Area, Fiber, vastus medialis, muscle, rat, Image analysis
Content, DNA, vastus medialis, muscle, rat, Biochemical
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Protocol / Approach
Proposal Date
Proposal Source
Hardware Items