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EXPERIMENT INFORMATION

Rodent Research 1 (RR-1) (ARC00XX146)
Research Area:
Technology development
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: C57BL/6J

Description
OBJECTIVES:

NASA's Rodent Research Hardware System (Rodent Research Habitat System) was designed for use as a research platform aboard the International Space Station (ISS) for long-duration rodent experiments in space. As with previous space life science experiment platforms, the system was designed to investigate the effects of microgravity on biological processes of direct relevance to humans in space in order to better understand the countermeasures needed to enable long-duration human spaceflight, to make discoveries in basic biology, and to acquire knowledge that would have a direct impact on human health on Earth.

On the maiden voyage of the Rodent Research Hardware System, dubbed Rodent Research-1, the payload was transported to the ISS on a SpaceX-4 CRS-4 Dragon cargo spacecraft.

NASA's primary objective for this mission was to validate the newly-developed RR1 hardware and demonstrate critical research operations, while supporting the Center for the Advancement of Science in Space (CASIS) in sponsoring the first commercial research study. NASA had no science objectives or principal investigators assigned to this preliminary mission. The agency's goals were to validate that the rodent research hardware could deliver and maintain healthy animals, that on-orbit activities to support the hardware operations could be performed, and that a limited set of generic on-orbit operations such as euthanasia, gross dissection, and sample preservation could be performed to support future science objectives. The CASIS research study objectives were to explore the molecular basis of muscle atrophy caused by extended microgravity exposure from spaceflight.


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Publications
Moyer EK, Dumars PM, Sun G-S, Martin KJ, Heathcote DG, Boyle RD, Skidmore MG. Evaluation of rodent spaceflight in the NASA animal enclosure module for an extended operational period (up to 35 days). npj Micrograv. 2016;2:16002. pubmed.gov

Choi S, Ray HE, Lai S-H, Alwood JS, Globus RK (2016) Preservation of Multiple Mammalian Tissues to Maximize Science Return from Ground Based and Spaceflight Experiments. PLoS ONE 11(12): e0167391. pubmed.gov

Choi, S.Y.; Cole, N.; Reyes, A.; San-Huei, S.; Klotz, R.; Beegle, J.E.; Wigley, C.L.; Pletcher, D.; Globus, R.K. NASA's Rodent Research Project: Validation of Capabilities for Conducting Long Duration Experiments in Space. 31st Meeting of the American Society for Gravitational and Space Research (ASGSR), Alexandria, VA, Nov 11-14, 2015. Oral Presentation. [NTRS]

Data Information
Data Availability
Archiving in Progress. Some data exist for this experiment.
Data Sets+ View data

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
SpaceX_4 09/20/2014 10/25/2014 35 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source
Hardware Items