(1) To investigate bone loss patterns in subjects exposed to microgravity. This shall be accomplished by using new non-invasive longitudinal three-dimensional measures of high-resolution peripheral quantitative computed tomography (HR-pQCT) of bone structure in addition to standard analysis techniques of DXA and analysis of biomarkers for bone formation and resorption.
(2) To determine parameters that may identify individuals with heightened sensitivity to sustained bone loss / loss of bone strength using the micro-structural parameter outcomes such as bone volume ratio and trabecular thickness, and magnitude and rate of bone loss.
There will be a 10.2 ml blood draw and a 48hour void-by-void urine collection. Bone biomarkers shall be quantified from the samples. Collection days are Launch minus 180 days (L-180d), L-60d ± 30d, Return to earth plus 180 days (R+180d), and R+360d. Where possible, data will be shared to TBone from either MedB Clinical Nutrition Assessment or HRP Biochemical Profile experiment. In the event that neither protocol is otherwise planned for a particular subject at the required time point, data collection specifically for TBone will be accomplished according to the HRP Biochemical Profile protocol.
DXA scans include a whole body scan and regional scans of both proximal femurs (hips), spine, calcaneus (heel), and wrist. The technician positions the crewmember for each scan. The scan data are stored as digital information on the densitometer’s computer; analysis is performed later by the technician and a summary report generated. DXA scans planned for L-360d to L-45d preflight and (R+12d ± 9d) and R+360d ± 15d postflight are expected to be shared to TBone from MedB11.1 Medical Assessment Test. DXA scans at R+180d ± 15d and R+360d ± 15d are specifically required for this experiment and will be performed using the MedB11.1 Medical Assessment Test protocol.
At each HR-pQCT scanning session, left and right distal radius as well as left and right distal tibia will be scanned. High-resolution CT images will be created from these scans from which bone micro-architecture can be quantified. The subject will complete a health history questionnaire that details a brief medical history, medications, and supplements in addition to a few vital statistics necessary for data analysis. Questions shall focus on bone health. One pre-flight HR-pQCT will be performed at L-80d ± 20d. Postflight, HR-pQCT scans are planned for R+12d ± 9d, R+180d ± 15d and R+360d ± 15d.
There are no specific in-flight operations required for this experiment. Data on in-flight blood and urine biomarkers will be obtained through data sharing. If the HRP Biochemical Profile is not part of the subject’s complement, only pre and post-flight data is required. Inflight food intake and exercise data will also be obtained through MedB Clinical Nutrition.
Results for this investigation are unavailable. This is an international experiment. NASA does not currently have an agreement with international space partners to archive their data in the LSDA.
|Mission||Launch/Start Date||Landing/End Date||Duration|
|Expedition 46||12/11/2015||03/02/2016||82 days|
|Expedition 47||03/02/2016||06/18/2016||108 days|
|Expedition 48||06/18/2016||09/06/2016||80 days|
|Expedition 49||09/06/2016||10/30/2016||54 days|
|Expedition 50||10/28/2016||04/09/2017||164 days|
|Expedition 51||04/09/2017||06/02/2017||55 days|
|Expedition 52||06/02/2017||09/02/2017||92 days|
|Expedition 53||09/02/2017||12/14/2017||102 days|
|Expedition 54||12/14/2017||02/27/2018||75 days|
|Expedition 55||02/27/2018||06/03/2018||96 days|
|Expedition 56||06/03/2018||10/04/2018||123 days|
|Expedition 57||10/04/2018||12/20/2018||77 days|
|Expedition 58||12/18/2018||In progress|
|Expedition 59||Future mission|