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EXPERIMENT INFORMATION

Effect of Deep Space Radiation on Human Hematopoietic Stem and Progenitor Cell Function (NCC958IIH00404)
Principal Investigator
Research Area:
Cell and molecular biology
Hematology
Immunology
Radiation biology
Species Studied
Scientific Name: Homo sapiens Species: Human
Scientific Name: Mus musculus Species: Mouse

Description
OBJECTIVES:
The original aims of this project were as follows: 1) Investigate the cellular consequences of exposing human hematopoietic stem (HSC) and progenitor (HPC) cells to an environment which simulates the radiation environment of deep space, 2) Examine the molecular consequences of exposing human hematopoietic stem cells to an environment which simulates the radiation environment of deep space, and 3) Design potential countermeasures to obviate or negate cellular and molecular damage discerned during the course of carrying out Aims 1 and 2.


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Keywords
Cell transformation
Cosmic radiation
DNA damage
Dose-response relationship, radiation
Hematopoietic stem cells
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Human hematopoietic cells

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

The Human Research Roadmap is located at: https://humanresearchroadmap.nasa.gov/

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Additional Information
Co-Investigators
Managing NASA Center
National Space Biomedical Research Institute (NSBRI)
Responsible NASA Representative
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
04/06/2004
Proposal Source
2003 Biomedical Research & Countermeasures 03-OBPR-04