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Impact of Spaceflight on Primary and Secondary Antibody Responses (Ground study); Tetanus Antibody Response by B cells in Space (TARBIS) (Flight study) (NNX13AN34G)
Principal Investigator
Research Area:
Cell and molecular biology
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: C57BL/6J

The spaceflight environment influences immune cell distribution, ex vivo responses to antigen, and cytokine expression. However, few studies have characterized the impact of the spaceflight environment on the host immune response following an in vivo immune challenge, particularly those involving B cells and antibody production. The International Space Station (ISS) provides an ideal laboratory within which investigators can explore this unique environment and its impact on the host response. Through the use of a mouse model (with an immune system that closely parallels that of humans), we will establish a link between exposure to the spaceflight environment and decrements in immune system activation. This study is significant because it will directly test the hypothesis that host immunological health will be compromised in space.

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Rettig TA, Nishiyama NC, Pecaut MJ, Chapes SK. Effects of skeletal unloading on the bone marrow antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice. Life Sci Space Res. 2019 Aug;22:16-28. Epub 2019 Jun 14. [DOI]

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress
NG-11 04/17/2019 232 days 18 hours

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source
2012 Space Biology NNH12Z