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Dose Tracker Application for Monitoring Crew Medication Usage, Symptoms, and Adverse Effects during Missions (Dose_Tracker)
Principal Investigator
Research Area:
Technology development
Species Studied
Scientific Name: Homo sapiens Species: Human

During space flight, the body undergoes a number of physiological changes that are expected to result in altered interactions with administered medications, but it is not yet known if, or to what extent, these actually occur. The potential for therapeutically relevant alteration in either pharmacokinetics (how the body handles administered medications) or pharmacodynamics (how administered medications act upon the body) has long been a concern.

This study had the following specific aims:

  1. Develop an iOS application for the collection of medication usage data from crewmember participants during their missions.
  2. Employ the application to collect inflight medication usage data to elucidate whether a) data suggest in-flight pharmacokinetic changes (alterations in how the body absorbs, distributes, metabolizes or excretes a medication), b) data suggest inflight pharmacodynamic changes (alterations in how the medication interacts with target molecules and biochemical pathways), or c) unusual side effects occur during flight (frequency or quality).
  3. Use the application with the same individuals pre-flight to collect ground medication usage data as a basis for comparing medication usage and effects in the same individuals.
  4. Acquire sufficient inflight medication usage data to provide the necessary variance and effect-size information required to properly power future studies when they are needed.

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Wotring VE and Smith LK. Dose Tracker Application for Collecting Medication Use Data from International Space Station Crew. Aerospace Medicine and Human Performance. 2020. January 1;91(1):41-45. [DOI]

Space flight

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Data Information
Data Availability
Archive is complete. Data sets are not publicly available but can be requested.
Data Sets+ Request data

Medication dose
Medication efficacy
Medication frequency
Medication side effects
Medication use

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Expedition 46 12/11/2015 03/02/2016 82 days
Expedition 47 03/02/2016 06/18/2016 108 days
Expedition 48 06/18/2016 09/06/2016 80 days
Expedition 49 09/06/2016 10/30/2016 54 days
Expedition 50 10/28/2016 04/09/2017 164 days
Expedition 51 04/09/2017 06/02/2017 55 days
Expedition 52 06/02/2017 09/02/2017 92 days
HERA Campaign 1 02/27/2014 09/11/2014 Four 7-day missions

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

The Human Research Roadmap is located at:

+ Click here for information of how this experiment is contributing to the HRP's path for risk reduction.

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Jessica Keune
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Proposal Date
Proposal Source
Directed Research