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EXPERIMENT INFORMATION

Developing Personalized Countermeasures for Sensorimotor Adaptability: A Bedrest Study (NCC958SA03801)
Principal Investigator
Research Area:
Sensorimotor Adaptation Team
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
This study aimed to identify and characterize a set of predictive measures that included: 1) behavioral tests to assess sensory bias and adaptability; 2) imaging to determine individual brain morphological and functional features; and 3) genotype markers for genetic polymorphisms that play a role in the neural pathways underlying sensorimotor adaptation. Information from this study will help in the design of sensorimotor adaptability training countermeasures that may be customized for each crewmember’s individual characteristics. The study was almost completely retrospective, in that no new bed rest or flight studies were required.

This study had the following specific aims:


  1. Determine whether baseline individual sensory biases and capabilities for strategic and plastic-adaptive responses predict both change and also the ability to re-adapt sensorimotor and functional performance after 70 days of bed rest or short/long-duration space flight. Investigators will determine if participants’ individual sensory biases in use of vision, vestibular, and proprioception as well as tests of strategic and long-term adaption predict the change from pre-to post-tests after bed rest or space flight and determine if those biases predict rates of re-adaptation in sensorimotor performance.
  2. Determine if baseline brain morphological and functional metrics predict both change and also the ability to re-adapt sensorimotor and functional performance after 70 days of bed rest or short/long-duration space flight. Investigators will determine if individual differences in regional brain volumes (structural MRI), white matter integrity (diffusion tensor imaging, or DTI), functional network integrity (resting state functional connectivity MRI), and sensorimotor adaptation task-related functional brain activation (functional MRI) predict pre to post levels of decrements and their rates of re-adaptation in sensorimotor performance.
  3. Determine if genetic markers predict both change and also the ability to re-adapt sensorimotor and functional performance after 70 days of bed rest or short/long-duration space flight. Investigators will determine whether genetic polymorphisms in Catechol-O-methyltransferase (COMT), dopamine receptor D2 (DRD2), brain-derived neurotrophic factor (BDNF), and genetic polymorphism of alpha2-adrenergic receptor are associated with pre to post levels of decrements in sensorimotor performance and rates of re-adaptation.


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Publications
Cassady K, Ruitenberg M, Koppelmans V, Reuter-Lorenz P, De Dios Y, Gadd N, Wood S, Riascos Castenada R, Kofman I, Bloomberg J, Mulavara A, and Seidler R. Neural predictors of sensorimotor adaptation rate and savings. Human Brain Mapping. 2018. April; 39(4):1516-31. pubmed.gov

Nair MA, Mulavara AP, Bloomberg JJ, Sangi-Haghpeykar H, and Cohen HS. Visual dependence and spatial orientation in benign paroxysmal positional vertigo. Journal of Vestibular Research. 2018;27(5-6):279-86. pubmed.gov

Goel R, De Dios YE, Gadd NE, Caldwell EE, Peters BT, Reschke MF, Bloomberg JJ, Oddsson LIE, and Mulavara AP. Assessing somatosensory utilization during unipedal postural control. Frontiers in System Neuroscience. 2017. April 11; 11:21. pubmed.gov

Ruitenberg MFL, De Dios YE, Gadd NE, Wood SJ, Reuter-Lorenz PA, Kofman I, Bloomberg JJ, Mulavara AP, and Seidler RD. Multi-day adaptation and savings in manual and locomotor tasks. Journal of Motor Behavior. 2018. September-October; 50(5):517-27. pubmed.gov

Keywords
Bed rest
Brain
Behavior
Vestibular function tests
Visual perception

Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

Parameters
Balance control
Brain-derived neurotrophic factor (BDNF)
Dopamine
Gray matter
Learning
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

The Human Research Roadmap is located at: https://humanresearchroadmap.nasa.gov/

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Additional Information
Managing NASA Center
NSBRI
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Eric Gallagher
Institutional Support
National Space Biomedical Research Institute (NSBRI)
Proposal Date
06/01/2014
Proposal Source
2013 HERO NNJ13ZSA002N-Crew Health (FLAGSHIP & NSBRI)