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Brain Gene Expression Signatures from Cerebrospinal Fluid Exosome RNA Profiling (ARC00XX152)
Principal Investigator
Research Area:
Biomedical countermeasures
Species Studied
Scientific Name: Species: Mouse

One of the current priorities of the NASA Human Research Program is to characterize and quantify the risk of Spaceflight-Associated Neuro-ocular Syndrome (SANS) associated with microgravity exposure during spaceflight. While the described SANS syndrome focuses on ocular symptoms, spaceflight has been also linked to a number of other central nervous system (CNS)-related signs and symptoms. This study will evaluate a method of investigating brain physiology, molecular pathways and processes that may be altered by increased intracranial pressure (ICP).

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Demographic data
Fold change gene expression
Gene expression

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

The Human Research Roadmap is located at:

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Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source
2012 Crew Health NNJ12ZSA002N