This project moved from an Internal Project to Grant, A Gene Expression and Histologic Approach to the Study of Cerebrospinal Fluid Production and Outflow in Hindlimb Suspended Rats (ARC00XX173). Data has been collected independently from the Gene Expression and Histologic Approach to the Study of Cerebrospinal Fluid Production and Outflow in Hindlimb Suspended Rats grant. Results are described below.
Our findings support new concepts regarding the communication between the immune and nervous systems. The IIH patients evidenced signs of generalized inflammation that may be affecting neural physiology at various levels, from neural signaling to cognition.16 These patients were predominantly obese (average BMI?=?34.7?±?7.4?kg/m2), with likely associated metabolic syndrome, chronic low-grade inflammation, and insulin resistance and other obesity-associated complications, for which pathways and processes were identified in the analysis. The value of this study predominantly lies in being the first evaluation of the molecular players in IIH and the first comparison between expression profiles from exosomes in CSF and plasma for this condition. Because elevation of ICP is a hallmark of the disease, findings from this study may be relevant to the SANS syndrome. The results from the CSF survey suggest neuro–immunomodulatory processes, and further work including astronauts exposed to microgravity and the concomitant fluid shifts with ICP increase, is proposed to test this hypothesis on a more relevant sample population.
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