The objectives of this application are to characterize the impact of spaceflight on female mouse retinal vasculature and tissue remodeling and to study the role of mitochondria in regulating oxidative stress-induced cellular damage and cell-cell interactions in the function of blood-retina-barrier (BRB). Our study will also determine the extent to which an antioxidant metalloporphyrin protects against spaceflight environment-induced changes in retinal neurovascular coupling and retinal function.
Together, our unique, integrative and quantitative activities with advanced MRI imaging techniques and retinal functional testing using visual electroretinography, will provide insight into the molecular mechanisms and pathways of spaceflight condition-induced mitochondrial oxidative damage on retinal BRB integrity, vascular remodeling, and retinal function. The data will provide unique criteria for risks of functional detriments associated with spaceflight. Our study will also lead to new information to understand the causes and possible treatments of similar Earth-based neurovascular-related diseases and retinal disorders and will point toward potential countermeasures.
This experiment is currently in progress. Results will be available at the conclusion of the study.
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