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Development and Testing of Biomarkers to Determine Individual Astronaut Vulnerabilities to Behavioral Health Disruptions (NNX14AK53G)
Principal Investigator
Research Area:
Behavior and performance
Species Studied
Scientific Name: Homo sapiens Species: Human

It is well established that sleep deficiency and circadian desynchrony impair alertness and performance. This is of concern given that chronic sleep loss is highly prevalent during space missions, which also often require maintenance of unusual sleep-wake and work schedules that the circadian system does not readily adapt to, further increasing sleepiness and reducing sleep. In such a high-risk environment, the risk of sleepiness-related performance impairment must be minimized. It is also increasingly recognized that the response to sleep loss and circadian desynchrony is highly individualized and both challenge- and task-dependent. This high degree of inter-individual variability makes it very difficult to predict who will be at risk and when they will be at risk, and therefore a ‘one-size-fits-all’ approach is likely to be suboptimal. What is needed are biomarkers of individual vulnerabilities and resiliencies to sleep loss and circadian desynchronization that can be used to predict problems and intervene when necessary.

To date, there are no biomarkers that are approved to determine individual astronauts’ vulnerabilities to sleep loss and circadian rhythm disruption, although there are many candidates to test. In a recent NASA Evidence Review addressing HRP Sleep Gap4, the investigator team identified and evaluated approximately 80 potential biomarkers of response to sleep loss or circadian desynchrony, ranging from simple subjective assessments of alertness through to genetic polymorphisms. While there are few data specifically characterizing individual responses to sleep loss and circadian desynchrony, fortunately, many of these biomarkers have been studied by their research group in detailed laboratory conditions of thousands of subjects over tens of thousands of bed-days in federally-funded studies, but have never been examined with respect to individual differences. Furthermore, in a previous NASA-supported study (ROSES-2008), investigators studied 51 Antarctic expeditioners over six months during the Antarctic winter (March to September) at Australian Antarctic stations Casey, Davis, and Mawson (54% of the overwintering population). A large number of subjective and objective measures of stress, affect, safety, team interactions, and well-being were recorded, in addition to subjective and objective measures of individual behavioral health outcomes including sleep, circadian rhythms, urinary cortisol, and melatonin levels, a range of neurocognitive performance outcomes and alertness. The large dataset is available to test the predictive value of a range of behavioral, performance, sleep, and circadian biomarkers on neurocognitive impairment and going forward, will allow the research team, in collaboration with HRP, to select only those measures that yield significant information for future study, and will allow the capacity to add new measures not yet assessed under these operational conditions.

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Biological markers
Circadian rhythm

Data Information
Data Availability
Archiving in Progress. Some restricted access data exist for this experiment.
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Circadian rhythm
Neurocognitive responses
Psychological responses
Sleep loss

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

The Human Research Roadmap is located at:

+ Click here for information of how this experiment is contributing to the HRP's path for risk reduction.

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Pamela A. Bieri
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source
2013 HERO NNJ13ZSA002N-Crew Health (FLAGSHIP & NSBRI)