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Rodent Tissue Repair: III. Skeletal Muscle (COS 2044-48)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar


Myofiber injury-repair was studied in the rat gastrocnemius following a crush injury to the lower leg prior to flight in order to understand if the regenerative responses of muscles are altered by the lack of gravitational forces during space flight. Skeletal muscle atrophy in actual or simulated weightlessness appears to be due to a combination of local and systemic factors' muscle tension and exogenous growth factors. If gravitational forces are necessary for optimal connective tissue organization and muscle repair, then muscle injuries in microgravity might require a special type of rehabilitation to prevent muscle fibrosis and/or movement dysfunction.

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Stauber, W.T. et al.: Connective Tissue Studies: III. Rodent Tissue Repair: Skeletal Muscle. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 2. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 255-269.

Stauber, W.T. et al.: Effect of Injury on Mast Cells of Rat Gastrocnemius Muscle with Respect to Gravitational Exposure. Experimental Molecular Pathology, vol. 59, no. 2, 1993, pp. 87-94.

Stauber, W.T. et al.: Effect of Spaceflight on the Extracellular Matrix of Skeletal Muscles After a Crush Injury. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. S74-S81.

Stauber, W.T. et al.: Extracellular Matrix Changes Following a Blunt Trauma to Rat Skeletal Muscles. Experimental Molecular Pathology, vol. 52, 1990, pp. 69-86.

Connective tissue
Cysteine endopeptidases
Multienzyme complexes
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Activity, enzymic, Proteases, gastrocnemius, muscle, rat, Immunohistochemical
Activity, enzymic, Proteinase, gastrocnemius, muscle, rat, Immunohistochemistry
Activity, Healing, repair process, gastrocnemius, muscle, rat, Histochemistry and immunohistochemistry
Activity, Healing, repair process, skin, gastrocnemius, soleus, fibula, rat, Histology and immunocytochemistry
Activity, Muscle, tissue repair, gastrocnemius, rat, Plasminogen activator (PA) and two serpin (PAI and PAI-I) assays
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Protocol / Approach
Proposal Date
Proposal Source
Hardware Items