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The Effects of Space Radiation on Stem Cells and Vascular and Cardiac Disease (NNX13AF05G)
Principal Investigator
Research Area:
Radiation health
Species Studied
Scientific Name: Species: Cells, human

The integrity of organs and tissues is maintained through continued cell production to replace damaged or senescent cells. In particular, stem cells are pivotal to this process providing the primary source for production of functional cells. In the heart, cardiac stem cells (CSCs) reside in close proximity to stromal cells or mesenchymal stem cells (MSCs) that produce proteins that control the growth and development. Stem cells are quiescent cells that cycle through self replication very slowly. This decreases the ability of these cells to repair damage to DNA and may lead to increased risks of vascular and heart disease. In this study, investigators aimed to evaluate the effects of exposure of stem cells to space flight-relevant radiation.

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Cell aging
Cell death
DNA damage
Radiation dosage
Radiation effects

Data Information
Data Availability
Archive is complete. Data sets are not publicly available but can be requested.
Data Sets+ Request data

DNA damage
Gamma H2AX
Gamma irradiation
HZE ion irradiation
Proton irradiation
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

The Human Research Roadmap is located at:

+ Click here for information of how this experiment is contributing to the HRP's path for risk reduction.

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Pamela A. Bieri
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source
2010 Space Radiobiology NNJ10ZSA001N