This study had the following specific aims:
Results suggest that female mice are somewhat resistant to iron irradiation while male mice appear to be more vulnerable, especially to the long-term central nervous system effects. One caveat is that survival was reduced in female Alzheimer’s mice exposed to the higher single dose of iron irradiation; however, those female Alzheimer’s mice that survived until the end of the study showed fewer radiation effects on cognition, amyloid pathology, and inflammation compared to their male irradiated counterparts. Iron-irradiated male but not female Alzheimer’s mice showed short- and long-term cognitive deficits and long-term increases in brain amyloid and neuroinflammation. Similar to iron irradiation, a single exposure to proton irradiation caused sex- and dose-specific effects that varied according to the mouse model (wildtype or Alzheimer’s). For example, motor coordination was worsened by low-dose (but not high dose) proton irradiation in wildtype mice but not Alzheimer’s mice, and improved by iron irradiation in Alzheimer’s mice. Both proton and iron irradiation induced spatial memory impairment in male but female Alzheimer’s mice. And, while iron irradiation increased brain amyloid, proton irradiation decreased brain amyloid in male Alzheimer’s mice. Lastly, a comparison of single dose versus six smaller, fractionated doses of the equivalent amount of total iron irradiation in male Alzheimer’s mice, using a new genetic knockin mouse model, revealed that fractionated dosing induced fewer detrimental effects than a single larger dose. For example, spatial memory deficits were observed following a single but not fractionated dose of iron irradiation. Neither single nor fractionated iron dosing altered brain amyloid levels in this new mouse model.
There are no data sets for this study. A final report was archived.
|Mission||Launch/Start Date||Landing/End Date||Duration|