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EXPERIMENT INFORMATION

Metabolic and Morphologic Properties of Muscle Fibers and Motor Neurons after Spaceflight: I. Muscle Fibers (COS 2044-27)
Principal Investigator
Research Area:
Muscle physiology
Neurophysiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

The present study allowed several issues raised by Cosmos 1887 to be addressed. These include the difference in atrophy suggested by wet muscle and fiber size data (40%), and the adaptability of selected metabolic enzymes to space flight. Also, a question not addressed in previous studies of tail-suspension or space flight is whether myosin ATPase activities of single fibers changes in parallel with the changes in expression of fast myosin.


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Publications
Bell, G.J. et al.: Altered Distribution of Mitochondria in Rat Soleus Muscle Fibers After Spaceflight. Journal of Applied Physiology, vol 73, no. 2, 1992, pp. 493-497.

Edgerton, V.R. and R.R. Roy: Regulation of Skeletal Muscle Fiber Size, Shape and Function. Journal of Biomechanics, supl., vol. 24, no. 1, 1991, pp. 123-133.

Edgerton, V.R. et al.: Metabolic and Morphologic Properties of Muscle Fibers and Motor Neurons after Spaceflight Cosmos 2044: I. Muscle Fibers. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 1. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 255-259.

Jiang, B. et al.: Adaptation of Fibers in Fast-Twitch Muscles of Rats to Spaceflight and Hindlimb Suspension. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. S58-S65.

Ohira, Y. et al.: Rat Soleus Muscle Fiber Responses to 14 Days of Spaceflight and Hindlimb Suspension. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. S51-S57.

Keywords
Glycerolphosphate dehydrogenase
Immunohistochemistry
Muscle fibers
Muscle, skeletal
Muscular atrophy
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Adenosine triphosphatase (ATPase), soleus, muscle, rat, Assay
Activity, enzymic, Glycolytic, glycogenic, oxidative enzymes, soleus, muscle, rat, Assay
Activity, enzymic, Reaction product, chemical, rat, Microscopy, optical density, activity (OD per minute)
Activity, enzymic, Succinate dehydrogenase (SDH), soleus, muscle, primate, Assay
Activity, enzymic, Succinate dehydrogenase (SDH), soleus, muscle, rat, Assay
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-14.1
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items