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Human Cerebral Autoregulation during Long-duration Spaceflight (Cerebral_Autoreg)
Principal Investigator
Research Area:
Cardiovascular physiology
Species Studied
Scientific Name: Homo sapiens Species: Human

In the previous Neurolab (STS-90) mission, a study showed that human cerebral autoregulation was preserved, and possibly even improved, by two weeks after space flight. However, the study might suffer from the small number of subjects or the special character of the mission as major limitations shared by most research in space. The specific aims of this study are to confirm reproducibility of the results from the Neurolab mission and to reveal the effects of prolonged space flight on cerebral circulation.

The main objective of the study is to determine the effects of short and long-duration space flight on cerebral blood flow autoregulation in humans by analyzing waveforms of arterial blood pressure and blood flow velocity in the middle cerebral artery recorded by transcranial Doppler (TCD).

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Cerebral arteries
Blood flow velocity

Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

Arterial blood pressure (ABP)
Cerebral autoregulation
Cerebral blood flow velocity (CBFV)

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Expedition 59 03/14/2019 06/24/2019 102 days
Expedition 60 06/24/2019 10/03/2019 101 days
Expedition 61 10/03/2019 02/06/2020 126 days
Expedition 62 02/06/2020 04/17/2020 70 days
Expedition 63 04/17/2020 10/21/2020 187 days
Expedition 64 10/21/2020 04/16/2021 177 days
Expedition 66 10/17/2021 03/30/2022 164 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Jessica Keune
Institutional Support
Japan Aerospace Exploration Agency (JAXA)
Proposal Date
Proposal Source