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DNA Damage Responses Induced By HZE Particles In Human Cells (NNA05CM04G)
Principal Investigator
Research Area:
Radiation health
Species Studied
Scientific Name: Species: Cells

The investigators utilized recent advances in knowledge of molecular mechanisms of DNA damage sensing, signaling, and repair, and changes in global gene expression patterns. Their specific aims were: 1) Test the hypothesis that HZE particles may induce a different gene expression profile than that induced by low LET radiation; 2) Verify the hypothesis that DNA double-strand breaks (DSB) induced by HZE particles are persistently unrejoined in normal human fibroblasts; 3) Test the hypothesis that HZE particles would induce a persistent and/or altered molecular and cellular response than that induced by X-rays in mammalian cells; and 4) Test the hypothesis that high HZE may generate factors that induce a bystander effect or bystander-like effect.

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Gene expression profiling
DNA damage
Gamma rays
HZE particles

Data Information
Data Availability
Archive is complete. Data sets are not publicly available but can be requested.
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Bystander effect
Chromosomal aberration
Radiation effects
Radiation response

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

The Human Research Roadmap is located at:

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Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source
2003 Biomedical Research & Countermeasures 03-OBPR-04