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Development and Validation of Therapeutic Ultrasound for Bloodless Surgery in Clinical Simulation in an Analog Environment (NCC958SMST04501)
Principal Investigator
Research Area:
Organismal biology
Species Studied
Scientific Name: genus Sus Species: Pig
Scientific Name: Homo sapiens Species: Human

As astronauts venture farther from Earth, the risks of medical crises increase. Ultrasound is a well-known imaging modality that has been successfully used on the International Space Station (ISS) to help mitigate these risks. In addition, there is potential to leverage advances in Earth-based clinical applications of high intensity focused ultrasound (HIFU) to enable non-invasive surgical treatments during exploration missions. HIFU therapies have the potential to treat a wide range of indications that could occur in future exploration missions, including stopping internal bleeding with acoustic hemostasis, treating cancerous tumors that may arise quickly from exposure to radiation, palliation of pain, or even acting as an acoustic scalpel to treat serious internal injuries noninvasively, through the skin.

To realize the potential of using HIFU with flexible ultrasound system (FUS) guidance in space, a suitable test-bed phantom is needed to provide a training apparatus for astronauts and test the delivery of therapy to targeted anatomical sites. The goal of this project was to develop such phantom with anatomical and acoustical features relevant to clinical HIFU such as skin, ribs, inhomogeneous body wall, and tissue targets to simulate thermal and mechanical HIFU treatments.

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Khokhlova TD, Haider YA, Maxwell AD, Kreider W, Bailey MR, and Khokhlova VA. Dependence of boiling histotripsy treatment efficiency on HIFU frequency and focal pressure levels. Ultrasound in Medicine and Biology. 2017. September; 43(9):1975-85. [DOI]

Technology assessment

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Frequency intensity

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Pamela A. Bieri
Institutional Support
National Space Biomedical Research Institute (NSBRI)
Proposal Date
Proposal Source
2015-16 HERO NNJ15ZSA001N