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Pilot Study of Otosclerosis (ARC00XX193)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: C57/B6


Sclerosis of the otic capsule in the inner ear eventually results in hearing loss. This is a common occurrence in the aging human population but also can occur in specific genetic conditions such as Pagets disease, osteogenesis imperfecta, and certain metabolic disorders . In addition, extreme noise, high pitched noise, or prolonged noise , can also induce damage to the hearing mechanism. Unfortunately, if otosclerosis is not treated early in its appearance (measured by hearing tests), the hearing loss and deafness may be permanent. Our immediate interest is whether animals that have been in space and in microgravity, will develop otosclerosis and subsequent hearing loss. This could be caused by constant noise, even at a normal pitch, or by the change in hydrostatic pressure within the skull that could affect the metabolism and function of the otic capsule. The presence of such sclerosis would suggest that the human crews in space may need to be monitored for hearing loss, and also strongly supports an animal flight experiment to study the cellular/molecular mechanisms responsible for development of otosclerosis and hearing loss. Such research would benefit not only the space program but also the aging population here on earth.

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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source