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Collection of Immune/Stress-related Tissues from Mice Flown on ISS (NNX15AB45G )
Research Area:
Cell and molecular biology
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: C57BL/6J

The Aims of this project will be to collect mouse liver, bone marrow, thymus, and adrenal glands (as part of the kidney). Our group is interested in the impact of space flight on the B cell response to tetanus toxoid antigen immunization. Thymus and adrenals will be used for the assessment of stress on the animals. In addition, space flight also impacts lymphocyte responses in an organ-specific manner. Therefore, we propose to collect liver and bone marrow to make comparative analyses of IgH gene usage to the already planned spleen analysis.

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Rettig TA, Ward C, Bye BA, Pecaut MJ, Chapes SK. Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing. PLoS One. 2018 Jan 10;13(1):e0190982. [DOI]

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
SpaceX_4 09/20/2014 10/25/2014 35 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source
2014 Space Biology NNH14Z