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EXPERIMENT INFORMATION

Gravitational Dose and Multi-system Physiologic Response (NNX16AO73G)
Research Area:
Biomedical countermeasures
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
Artificial Gravity (AG) substitutes for missing gravitational cues and loading in space and offers significant promise as an effective and efficient countermeasure against virtually all of the identified risks associated with bone loss, muscle weakening, cardiovascular deconditioning, and sensorimotor disturbances. However, the optimal AG load required for maintaining normal physiological function is unknown. Even with an AG capability, exercise is very likely to remain in the countermeasure suite because it provides additional physiological and psychological benefits. It is necessary, in understanding AG, to evaluate how AG interacts with exercise and how this interaction is influenced by partial gravity between 0 and 1 G. Parabolic flight creates the only condition that allows assessment of the effects of partial gravity in humans without the need for launching into space.

On this basis, parabolic flight research, with a range of gravitational loads, will provide a unique model to characterize the relationships among gravitational dose, exercise and the acute physiologic responses of the sensorimotor, cardiovascular, cerebrovascular, and ocular systems. This study will identify the AG dose-physiological response relationship and will involve a multidisciplinary collaboration between investigators at the Johnson Space Center with the collective expertise in cardiovascular physiology, exercise physiology, muscle physiology, sensorimotor function, and statistical analyses. The primary aims are to characterize the effects of varying gravity on VIIP-related outcomes, cardiovascular, cerebrovascular and ocular hemodynamics and pressures, calf muscle activation, neuro/vestibular outcomes associated with dynamic visual acuity, outcomes related to locomotion with body weight replacement and kinematics, and importantly, the co-relations that may exist among these physiological areas.


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Keywords
25-Hydroxycholecalciferol
Electromyography
Exercise/physiology
Ocular physiology
Visual acuity
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Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

The Human Research Roadmap is located at: https://humanresearchroadmap.nasa.gov/

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Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Pamela A. Bieri
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
07/26/2016
Proposal Source
2015-16 HERO NNJ15ZSA001N