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EXPERIMENT INFORMATION

The Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status during Adaptation to Spaceflight (Food_Physiology)
Principal Investigator
Research Area:
Gastrointestinal physiology
Immunology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
Given the associations between diet, the gut microbiota, and immune response investigators will be assessing multiple nutritional biomarkers and metabolites, immunological biomarkers, and the gut microbiota in relation to diet and are expecting to associate multiple benefits between nutrient intake and nutritional biomarkers and metabolites in relation to immune and microbiome health. It is expected that by determining shifts in nutritional and immunological biomarkers and the taxonomic and metatranscriptomic profiles of the gut microbiota associated with two different space flight diet regimes investigators may be able to understand how diet impacts human adaptation to space flight, begin to characterize a healthy status in relation to diet, and indicate where alterations in diet may best improve physiological status. This work is significant as the first step towards determining the associated effect of increasing the consumption of specific bioactive compounds, fruits, and vegetables, on human health and adaptation to space flight, specifically related to the immune system and gut microbiota, which will guide future food system development efforts towards efficient dietary interventions and improved overall health, and ultimately the success of long duration human exploration missions.


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Keywords
Immune system
Gastrointestinal system

Photo Gallery
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Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

Parameters
8-hydroxy-2-deoxyguanosine
8-iso-prostaglandin F2a
Acetate
Alanine aminotransferase (ALT)
Albumin
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Expedition 61 10/03/2019 02/06/2020 126 days
Expedition 62 02/06/2020 04/17/2020 70 days
Expedition 63 04/17/2020 10/21/2020 187 days
Expedition 65 04/16/2021 10/17/2021 184 days
Expedition 66 10/17/2021 In progress
HERA Campaign 4 05/06/2017 06/18/2018 Four 45 days One 23 days

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

The Human Research Roadmap is located at: https://humanresearchroadmap.nasa.gov/

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Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Jessica Keune
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
09/01/2016
Proposal Source
2014 Space Biology Flight