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Omics and Biochemical Markers of Cardiovascular and Bone Health: Relationship with Bedrest and Standard Physiological Measures (NNX16AR26G)
Principal Investigator
Research Area:
Biomedical countermeasures
Species Studied
Scientific Name: Homo sapiens Species: Human

The long-range goal of this research was to identify and characterize the omics and biochemical mechanisms that underlie the changes in cardiovascular and musculoskeletal function following prolonged space flight. It is well established that microgravity elicits central and peripheral decrements within the cardiovascular system. Traditional cardiovascular measurements have demonstrated significant decreases in left ventricular volume and mass within only a few weeks of exposure. Similarly, human and animal models suggest that microgravity exposure significantly alters vasomotor reactivity to various physiologic stressors. However, despite the recognition that cardiovascular function is decreased with prolonged microgravity exposure, the mechanistic underpinnings of these changes are not completely understood. In addition to changes within the cardiovascular system, significant decreases in bone health occur with prolonged microgravity. These changes are mediated, in part, due to general deconditioning and muscular/mechanical unloading that occurs with microgravity. As such, the average monthly rate of loss in areal bone mineral density can reach 1.0-1.5% when measured over a 14 month period. Given the significant and time-dependent changes in cardiovascular function and bone health associated with microgravity exposure, a continued evaluation of these systems is required, particularly within the genomic and biochemical sciences.

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Ade CJ, and Bemben DA. Differential microRNA expression following head-down tilt bed rest: Implications for cardiovascular responses to microgravity. Physiological Reports. 2019. May; 7(9):e14061. [DOI]

Cardiovascular physiology

Data Information
Data Availability
Archive is complete. Data sets are not publicly available but can be requested.
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Ventricular volume

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

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Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source
2014-15 HERO NNJ14ZSA001N