Medical Proteome Analysis of Osteoporosis and Bone Mass-related Proteins using the Kibo Japanese Experiment Module of International Space Station (Medical_Proteomics)
Scientific Name: Homo sapiens Species: Human
Investigators aim to study changes in blood proteins of astronauts before and after space flight by using the latest proteome analysis technique, and identify the causal protein of osteopenia. If protein changes due to osteopenia in space is understood, it is possible to clarify not only the cause of the osteopenia, but also the proteins that cause osteoporosis on the ground. This research will provide the knowledge in order to maintain astronauts’ health, as well as results to contribute to disease countermeasures on the ground.
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Blood will be drawn three times during preflight, four times inflight, and five times postflight. The samples will be anonymized, identification numbered, and then, proceeded and frozen under -80 degree C. The PI team will receive all the tubes at the same time after all subjects’ sessions are complete. Proteomics will be performed in order to clarify the relevance between osteopenia in none-load environment by microgravity and osteoporosis on the ground.
This study is in progress. NASA does not have an agreement to archive data from International Partners.
Archiving in progress. Data is not yet available for this experiment.
Bone alkaline phosphatase (BAP), serum
N-terminal telopeptide (NTX), serum
Procollagen I intact N-terminal propeptide (PINP), serum
Tartrate-resistant acid phosphatase 5b (TRACP 5b), serum
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Terry Hill
Japan Aerospace Exploration Agency (JAXA)