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Rodent Research 3 (RR3) (ARC00XX198)
Research Area:
Muscle physiology
Radiation biology
Skeletal physiology
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: BALB/c


The Rodent Research 3 (RR3) science investigation was sponsored by the Center for the Advancement of Science in Space (CASIS) in collaboration with Eli Lilly Company. The primary science objective of the mission was to evaluate muscle atrophy in microgravity conditions and to determine if inhibiting myostatin, a protein that negatively regulates muscle growth, could prevent the loss of muscle. Additional objectives were to assess whether preventing muscle wasting could mitigate the loss of bone mineral density under microgravity conditions and, through post-flight analysis, to quantify the effects of spaceflight on molecular markers of muscle atrophy and bone loss, with and without the myostatin inhibition.

Results from this investigation could lead to the reduction of negative impacts of spaceflight on the musculoskeletal systems of astronauts. Translational applications might include the development of treatments for muscle loss caused by ground-based diseases, disorders, and injuries, including muscular dystrophy, extended bed rest, advanced aging, casting, cancer cachexia, and kidney failure.

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Data Information
Data Availability
Archiving in Progress. Some data exist for this experiment.
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
SpaceX_8 04/08/2016 05/11/2016 33 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source