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Investigating Space Microgravity Effects on Antibiotic Resistance of E. coli (EcAMSat) (ARC00XX210)
Research Area:
Species Studied
Scientific Name: Escherichia coli Species: Bacteria

The E. coli AntiMicrobial Satellite (EcAMSat) mission investigated space microgravity effects on the antibiotic resistance of E. coli, a bacterial pathogen responsible for urinary tract infection in humans and animals. EcAMSat was being developed through a partnership between NASA’s Ames Research Center and the Stanford University Department of Microbiology and Immunology.

EcAMSat investigated spaceflight effects on bacterial antibiotic resistance and its genetic basis. Bacterial antibiotic resistance may pose a danger to astronauts in microgravity, where the immune response is weakened. Scientists believe that the results of this experiment could help design effective countermeasures to protect astronauts’ health during long-duration human space missions.

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Matin AC, Wang JH, Keyhan M, Singh R, Benoit M, Parra MP, Padgen MR, Ricco AJ, Chin M, Friedericks CR, Chinn TN, Cohen A, Henschke MB, Snyder TV, Lera MP, Ross SS, Mayberry CM, Choi S, Wu DT, Tan MX, Boone TD, Beasley CC, Spremo SM. Payload hardware and experimental protocol development to enable future testing of the effect of space microgravity on the resistance to gentamicin of uropathogenic Escherichia coli and its ss-deficient mutant. Life Sci Space Res. 2017 May 10. [DOI]

Padgen MR, Lera MP, Parra MP, Ricco AJ, Chin M, Chinn TN, Cohen A, Friedericks CR, Henschke MB, Snyder TV, Spremo SM, Wang J-H, Matin AC. EcAMSat spaceflight measurements of the role of ss in antibiotic resistance of stationary phase Escherichia coli in microgravity. Life Sci Space Res. 2019 Oct 31. [DOI]

Padgen MR, Chinn TN, Friedericks CR, Lera MP, Chin M, Parra MP, Piccini ME, Ricco AJ, Spremo SM. The EcAMSat fluidic system to study antibiotic resistance in low Earth orbit: Development and lessons learned from space flight. [DOI]

Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

Escherichia coli

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
OA_8 11/12/2017 12/06/2017 24 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source
Internal Project