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EXPERIMENT INFORMATION

Measurement of Heart Atrial Natriuretic Peptide Concentrations (COS 2044-13)
Principal Investigator
Research Area:
Cardiovascular physiology
Endocrinology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Although fluid-electrolyte balance has not been determined during flight, postflight hormone measurement and salt water loading experiments indicate that rats also respond to microgravity by readjustment of their fluid-electrolyte requirements. Atrial natriuretic peptide (ANP) secretion is regulated primarily by atrial pressure. The purpose of the experiment was to determine if space flight exposure had an effect on the concentration of ANP.


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Publications
Keil, L.C. et al.: Natriuretic Peptide Content of Atria from Rats Exposed to 14 Days of Spaceflight. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 1. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 374-379.

Keywords
Adaptation, physiological
Atrial natriuretic factor (ANF)
Heart atrium
Hindlimb
Immobilization
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Composition, Hematocrit, blood, rat, clinical laboratory
Content, Atrial natriuretic peptide (1-28 ANP), myocardium, heart, rat, Radioimmunoassay, displacement
Content, Atrial natriuretic peptide (1-28 ANP), rat, Radioimmunoassay, displacement
Content, Protein, myocardium, heart, rat

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-1
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items