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EXPERIMENT INFORMATION

Biomechanical, Biochemical, and Morphological Alterations of Muscle and Dense Fibrous Connective Tissues: II. Composition of the Invertebral Disk (COS 2044-31)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

The intervertebral disc is formed by three structures: the nucleus pulposus (NP), the annulus fibrosis (AF), and the cartilaginous endplates (EP). This study was designed to determine the effects of weightlessness on the size, water content, and composition of the lumbar annuli intervertebral disc in space-flown rats. Changes in the composition of the AF may render it unable to withstand swelling pressures of the NP and/or the stress and strain associated with movement under load, making the return to normal gravitational fields potentially hazardous.


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Publications
Pedrini-Mille, A. et al.: Biomechanical, Biochemical, and Morphological Alterations of Intramuscular and Dense Fibrous Connective Tissues After 14 Days Spaceflight: II. Effects of Microgravity on the Composition of the Invertebral Disc. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 1. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 153-186.

Pedrini-Mille, A. et al.: Effects of Microgravity on the Composition of the Intervertebral Disc. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. 26S-32S.

Keywords
Aging
Body water
Intervertebral disk
Collagen
Proteoglycans

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Composition, Hydroxyproline, lumbar annuli intervertebral disc, rats, Biochemical analysis
Composition, Proteoglycans, lumbar annuli intervertebral disc, rats, Biochemical analysis
Composition, Pyridinoline crosslinks, collagen fibrils, lumbar annuli intervertebral disc, rats, Biochemical analysis
Content, Water, intervertebral disk, rat, Calculation
Morphology, Collagen fibrils, lumbar annuli intervertebral disc, rats, Light/electron microscopy, observation
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-16.2
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items