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EXPERIMENT INFORMATION

Hepatic Function in Rats After Spaceflight: I. Analyses of Selected Parameters of Carbohydrate, Amino Acid, Lipid, and Xenobiotic Metabolism (COS 2044-5)
Principal Investigator
Research Area:
Metabolism and nutrition
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Since the liver is basically a central "clearing house" for the metabolism of most nutrients, drugs, and other foreign compounds, further studies of the effects of space flight on the organ appeared warranted. Previous findings suggest that the xenobiotic metabolism is altered by space flight. In attempts to further these findings, described in this report are additional data from analyses of liver samples and serum samples from space-flown rats.


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Publications
Merrill, A.H. et al.: Analyses of Plasma for Metabolic and Hormonal Changes in Rats Flown Aboard Cosmos 2044. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. 132S-135S.

Merrill, A.H. et al.: Differences in Glycogen, Lipids, and Enzymes in Livers from Rats Flown on Cosmos 2044. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. 142S-147S.

Merrill, A.H. et al.: Hepatic Function in Rats After Spaceflight: I. Analyses of Selected Parameters of Carbohydrate, Amino Acid, Lipid, and Xenobiotic Metabolism in Liver and Serum. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 1. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 463-470.

Keywords
Amino acids
Carbohydrates
Hydroxymethylglutaryl CoA reductases
Lipids
Liver
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Alkaline phosphatase (AP), serum, rat, Analyzer
Activity, enzymic, Carbohydrate, lipid metabolism, liver, rat, Assay
Activity, enzymic, Lactate dehydrogenase (LDH),serum, rat, Assay
Content, Cholesterol, liver, rat, Clinical analysis
Content, Cytochrome-c, liver, rat, Clinical analysis
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-21.1
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items