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Neuroendocrine and Immune Responses in Humans during and After Long Term Stay at ISS (IMMUNO)
Principal Investigator
Research Area:
Species Studied
Scientific Name: Homo sapiens Species: Human

Immuno will determine neuroendocrine and immunological changes during and after working and living on the International Space Station (ISS). A focus on cellular energy metabolism and cell signaling will provide additional information on the psycho-neuroendocrine and immunologic adaptation of human physiology to space and a better insight on how these processes are dependent on the cellular level of signal processing. The aim of this experiment was to determine changes in stress and immune responses, during and after a stay on the ISS. This included the sampling of saliva, blood and urine to check for hormones associated with stress response and for carrying out white blood cell analysis.

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Morukov BV, Rykova MP, Antropova EN, Berendeeva T, Ponomaryov S,and Larina IM. T-cell immunity and cytokine production in cosmonauts after long-duration space flights. Acta Astronautica. 2011; 68: 739-746.

Rykova MP, Antropova EN, Larina IM, and Morukov BV. Humoral and cellular immunity in cosmonauts after the ISS mission. Acta Astronautica. 2008; 63: 697-705.

Strewe C, Feuerecker M, Nichiporuk IA, Kaufmann I, Hauer D, Morukov BV, Schelling G, and Chouker A. Effects of parabolic flight and spaceflight on the endocannabinoid system in humans. Reviews in the Neurosciences. 2012. September; 23(5-6): 673-680. []

Adaptation, physiological
Stress, psychological
Time factors

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

B lymphocytes
Natural killer cell cytotoxic activity
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Expedition 15 04/07/2007 10/21/2007 197 days
Expedition 16 10/10/2007 04/19/2008 192 days
Expedition 20 05/27/2009 10/11/2009 137 days
Expedition 21 10/11/2009 12/01/2009 51 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Jessica Keune
Institutional Support
European Space Agency (ESA)