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EXPERIMENT INFORMATION

Rat Testis Morphology and Physiology (COS 2044-2)
Principal Investigator
Research Area:
Endocrinology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

There is seemingly contradictory evidence on the effects of space flight on testicular function in mammals. The reason for abnormalities of the endocrine and possible exocrine (spermatogenic) functions of the testes are unknown, but could be related to altered function of the hypothalamus or adenohypophysis, altered fluid distribution in the body, and/or restricted blood and lymph flow within the testes. In this study, histology and testicular gene expression were studied to evaluate effects of space flight on testicular function.


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Publications
Amann, R.P. et al.: Effect of Microgravity or Simulated Launch on Testicular Function in Rats. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. S174-S185.

Amann, R.P. et al.: Effects of Microgravity or Simulated Launch on Testicular Function in Rats. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 2. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 3-24.

Deaver, D.R. et al.: Effects of Caudal Elevation on Testicular Function in Rats: Separation of Effects on Spermatogenesis and Steroidogenesis. J. Androl., vol. 13, 1992, pp. 224-231.

Keywords
Gene expression regulation
Genetic markers
Gonadotropins, chorionic
Heat-shock proteins
Leydig cells
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Area, cross section, Seminiferous tubules, testes, rat, Microscopy
Cell function: Leydig cell
Cell ultrastructure: Leydig cell
Content, Testosterone, plasma, rat, immuno-assay
Count, Sertoli cells, testes, rat, Histochemistry, microscopy
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-22
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items