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EXPERIMENT INFORMATION

Structural Changes and Cell Turnover in the Rat's Small Intestine Induced by Spaceflight. (COS 2044-3)
Principal Investigator
Research Area:
Metabolism and nutrition
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

The purpose of this project was to test the hypothesis that the generalized, whole- body decrease in synthetic activity due to microgravity conditions encountered during space flight would be demonstrable in cells and tissue characterized by a rapid rate of turnover. Jejunal mucosal cells were chosen as a model since these cells are among the most proliferative in the body.


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Publications
Phillips, R.W. et al.: Effects of Spaceflight on the Proliferation of Jejunal Mucosal Cells. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044. Vol. 2. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-108802, 1994, pp. 25-32.

Sawyer, H.R. et al.: Proliferation of Jejunal Mucosal Cells in Rats Flown in Space. Journal of Applied Physiology, supl., vol. 73, no. 2, 1992, pp. S148-S150.

Keywords
Microvilli
Intestinal mucosa
Jejunum
Mitosis

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Morphology, Cell proliferation, mucosal cells, jejunum, rat, Microscopy
Morphology, Crypts of Lieberkuhn, depth, jejunum, rat, Microscopy
Morphology, Jejunum, crypts, villi, mitotic index, rat, Microscopic (descriptive, counts)
Morphology, Mucus membrane, gastric (stomach), rat, Microscopic (no units)
Morphometry, Crypts of Lieberkuhn, mitotic index, jejunum, rat, Microscopy
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2044 09/15/1989 09/29/1989 14 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C2044-23
Protocol / Approach
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items