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EXPERIMENT INFORMATION

Long Term Microgravity: A Model for Investigating Mechanisms of Heart Disease with New Portable Equipment, and Mechanisms of Activation of Sympathoadrenal Activity in Humans during Spaceflight (99_081_MAP)
Research Area:
Cardiovascular physiology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
In this experiment, investigators aimed to test how the cardiovascular system adapts to prolonged weightlessness and whether the circulation is chronically dilated in space. Furthermore, it investigated whether there is a mismatch between the level of sympathetic nervous activity and dilatation of the peripheral vessels.

Investigators sought to compare the 24-hour ambulatory cardiovascular data from space with similar data collected in heart failure patients on the ground. This indicates to what degree gravity plays a role in mechanisms of heart failure.


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Publications
Norsk P, Asmar A, Damgaard M, and Christensen NJ. Fluid shifts, vasodilatation and ambulatory blood pressure reduction during long duration spaceflight: Vasodilatation and ambulatory blood pressure during spaceflight. Humans in Space Symposium (HIS) 2015; 20th; 29 June - 3 July 2015; Prague; Czechoslovakia. NASA Johnson Space Center; Houston, TX, United States. June 29, 2015. [NTRS]

Norsk P, Asmar A, Damgaard M, and Christensen NJ. Fluid shifts, vasodilatation and ambulatory blood pressure reduction during long duration spaceflight: Vasodilatation and ambulatory blood pressure during spaceflight. Journal of Physiology. 2015. February 1; 593(3): 573-584. [DOI]

Keywords
Cardiovascular physiology

Photo Gallery
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Blood pressure, continuous
Cardiac output
Catecholamine concentrations
Humidity
Pressure
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Expedition 14 09/18/2006 04/21/2007 215 days
Expedition 19 03/26/2009 10/11/2009 199 days
Expedition 20 05/27/2009 10/11/2009 137 days
Expedition 21 10/11/2009 12/01/2009 51 days
Expedition 22 11/30/2009 03/18/2010 109 days
Expedition 25 09/24/2010 11/25/2010 31 days
Expedition 26 11/26/2010 03/16/2011 111 days
Expedition 27 03/14/2011 05/23/2011 70 days
Expedition 30 11/14/2011 04/27/2012 166 days
Expedition 31 04/27/2012 07/01/2012 65 days
Expedition 32 07/01/2012 09/16/2012 78 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Eric Gallagher
Institutional Support
European Space Agency (ESA)
Alternate Experiment Name
CARD
Proposal Source
International
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